Publications on CHEF projects through 2007:
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Grandjean P, Weihe P, Jørgensen PJ, Clarkson T, Cernichiari E, Viderø T. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch Environ Health 1992; 47: 185-95.
Grandjean P, Weihe P. Neurobehavioral effects of intrauterine mercury exposure: potential sources of bias. Environ Res 1993; 61: 176-83.
Olsen S, Grandjean P, Weihe P, Viderø T. Seafood intake in pregnancy as a determinant of birth weight: Evidence for a dose-dependent relationship. J Epidemiol Comm Health 1993; 47: 436-40.
Grandjean P, Jørgensen PJ, Weihe P. Human milk as a source of methylmercury exposure in infants. Environ Health Perspec 1994; 102: 74-7. Weihe P, Grandjean P. Sources and magnitude of mercury exposure in the Faroe Islands, overall design of the cohort study. Proceedings of the international symposium on assessment of environmental pollution and health effects of methylmercury, Kumamoto, 1994, pp. 112-26.
White RF, Debes F, Dahl R, Grandjean P. Development and field testing of a neuropsychological test battery to assess the effects of methylmercury exposure in the Faroe Islands. Ibid., pp. 127-40.
Araki S, Murata K, Yokoyama K, Okajima F, Grandjean P, Weihe P. Neuroelectrophysiological study of children in low-level methylmercury exposure in the Faroe Islands: Methodology and preliminary findings. Ibid., pp. 141-51.
Grandjean P, Weihe P. Neurobehavioral effects of intrauterine methylmercury exposure: Bias problems in epidemiological studies. Ibid., pp. 152-62.
Dalgård C, Grandjean P, Jørgensen PJ, Weihe P. Mercury in the umbilical cord: Implications for risk assessment for Minamata disease. Environ Health Perspec 1994; 102: 548-50.
Grandjean P, Weihe P, Nielsen JB. Methylmercury: Significance of intrauterine and postnatal exposures. Clin Chem 1994; 40: 1395-1400.
Grandjean P, Weihe P, White RF. Milestone development in infants exposed to methylmercury from human milk. Neurotoxicol 1995; 16: 27-33.
Grandjean P, Weihe P, Needham LL, Burse VW, Patterson DG Jr, Sampson EJ, Jørgensen PJ, Vahter M. Relation of a seafood diet on mercury, selenium, arsenic, and PCBs and other organochlorines in human milk. Environ Res 1995; 71: 29-38. White RF, Grandjean PA, Weihe P. An overview of human studies on CNS effects of methylmercury. Proceedings of the National Forum on Mercury in Fish. (Publication EPA 823-R-95-002). Washington, DC: U.S.Environmental Protection Agency, 1995, pp. 109-112.
Grandjean P, White RF, Weihe P. Neurobehavioral epidemiology: Application in risk assessment. Environ Health Perspec 1996; 104 (Suppl.2): 397-400.
Weihe P, Grandjean P, Debes F, White R. Health implications for Faroe Islanders of heavy metals and PCBs from pilot whales. Sci Tot Environ 1996; 186: 141-8.
Dahl R, White RF, Weihe P, Sørensen N, Letz R, Hudnell K, Otto DA, Grandjean P. Feasibility and validity of three computer-assisted neurobehavioral tests in 7-year old children. Neurotoxicol Teratol 1996; 18: 413-9.
Grandjean P, Weihe P, White RF, Debes F, Araki S, Murata K, Sørensen N, Dahl D, Yokoyama K, Jørgensen PJ. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 1997; 19: 417-28.
Weihe P, Grandjean P. Methylmercury risks (letter). Science 1998; 279: 639. Grandjean P, Weihe P. A new era of mercury hazards (editorial). Environ Res 1998; 77: 67.
Grandjean P, Weihe P, White RF, Debes F. Cognitive performance of children prenatally exposed to ‘safe’ levels of methylmercury. Environ Res 1998; 77: 165-72.
Akagi H, Grandjean P, Takizawa Y, Weihe P. Methylmercury dose estimation from umbilical cord concentrations in patients with Minamata disease. Environ Res 1998; 77: 98-103.
Grandjean P, White RF. Effects of methylmercury exposure on neurodevelopment (letter). JAMA 1999; 281: 896.
Budtz-Jørgensen E, Keiding N, Grandjean P, White RF, Weihe P. Methylmercury Neurotoxicity Independent of PCB Exposure (letter). Environ Health Perspect 1999; 107: A236-7.
Sørensen N, Murata K, Budtz-Jørgensen E, Weihe P, Grandjean P. Prenatal methylmercury exposure as a cardiovascular risk fact. Epidemiol 1999; 10(4): 370-5.
Murata K, Weihe P, Araki S, Budtz-Jørgensen E, Grandjean P. Evoked potentials in Faroese children prenatally exposed to methylmercury. Neurotoxicol Teratol 1999; 21(4): 471-2.
Grandjean P, Budtz-Jørgensen E, White RF, Jørgensen PJ, Weihe P, Debes F, Keiding N. Methylmercury exposure biomarkers as indicators of neurotoxicity in 7-year-old children. Am J Epidemiol 1999; 150(3): 301-5.
Grandjean P. Mercury Risks: Controversy or Just Uncertainty? Publ Health Rep 1999; 114(6): 512-5.
Steuerwald U, Weihe P, Jørgensen PJ, Bjerve K, Brock J, Heinzow B, Budtz-Jørgensen E, Grandjean P. Maternal seafood diet, methylmercury exposure, and neonatal neurological function. J Pediatr 2000; 136(5): 599-605.
Budtz Jørgensen E, Grandjean P, Keiding N, White RF, Weihe P. Benchmark dose calculations of methylmercury-associated neurobehavioural deficits. Toxicol Lett 2000; 112-3: 193-9. Nielsen JB, Nielsen F, Jørgensen PJ, Grandjean P. Toxic metals and selenium in blood from pilot whale (Globicephala melas) and sperm whale (Physeter catodon). Marine Pollut Bull 2000; 40: 348-51.
Grandjean P, Bjerve KS, Weihe P, Steuerwald U. Birth weight in a fishing community: significance of essential fatty acids and marine food contaminants. Int J Epidemiol 2001; 30(6): 1272 8.
Budtz-Jørgensen E, Keiding N. Grandjean P. Benchmark dose calculation from epidemiological data. Biometrics 2001; 57(3): 698 706.
Grandjean P, White RF, Sullivan K, Debes F, Murata K, Otto DA, Weihe P. Impact of contrast sensitivity performance on visually-presented neurobehavioral tests in mercury-exposed children. Neurotoxicol Teratol 2001; 23(2): 141-6. Grandjean P, White RF. Neurobehavioral dysfunction as possible sentinel. Hum Ecol Risk Assess 2001; 7: 1079-89.
Grandjean P, Weihe P, Burse VW, Needham LL, Storr-Hansen E, Heinzow B, Debes F, Murata K, Simonsen H, Ellefsen P, Budtz-Jørgensen E, Keiding N, White RF. Neurobehavioral deficits associated with PCB in 7-year-old children prenatally exposed to seafood neurotoxicants. Neurotoxicol Teratol 2001; 23(4): 305 17. Murata K, Weihe P, Araki S, Grandjean P. Delayed evoked potentials in children exposed to methylmercury from seafood: Madeira and Faroe Islands. In; Proceedings of US-Japan workshop on human health effects of low dose methylmercury exposure. Minamata: National Institute for Disease, 2001, pp. 90-106.
Fängström B, Athanassiadis I, Athanasiadou M, Grandjean P, Weihe P, Bergman Å. Hydroxylated PCB metabolites in non-hatched Faroe Island fulmar eggs. Organohalogen Compounds 2001; 49: 112-5.
Grandjean P, Jørgensen PJ, Weihe P. Validity of mercury exposure biomarkers. In: Wilson SH, Suk WA, Eds. Biomarkers of Environmentally Associated Disease. Boca Raton, FL, CRC Press/Lewis Publishers, 2002, pp. 235-47.
Budtz-Jørgensen E, Keiding N, Grandjean P, Weihe P. Estimation of health effects of prenatal methylmercury exposure using structural equation models. Environ Health 2002; 1(1):2
Grandjean P, White RF. Developmental effects of environmental neurotoxicants. In: Tamburlini G, von Ehrenstein O, Bertollini R, eds. Children’s health and environment. Environmental issue report No. 29. Copenhagen: European Environment Agency, 2002, pp. 66-78.
Lanzirotti A, Jones KW, Clarkson TW, Grandjean P. Human health risks from methyl mercury in fish. Science Highlights – National Synchroton Light Source Activity Report. Upton, NY: Brookhaven National Laboratory, 2002, pp. 97-9.
Mol NM, Sørensen N, Weihe P, Andersson A-M, Jørgensen N, Skakkebæk NE, Keiding N, Grandjean P. Spermaturia and serum hormone concentrations at puberty age in boys prenatally exposed to polychlorinated biphenyls. Eur J Endocrinol 2002; 146(3): 357-63.
Murata K, Budtz-Jørgensen E, Grandjean P. Benchmark dose calculations for methylmercury-associated delays on evoked potential latencies in children. Risk Anal 2002; 22: 465-74.
Murata K, Dakeishi M. Impact of prenatal methylmercury exposure on child neurodevelopment in the Faroe Islands. Nippon Eiseigaku Zasshi 2002; 57(3): 564-70. Japanese.
Weihe P, Hansen JC, Murata K, Debes F, Jørgensen PJ, Steuerwald U, White RF, Grandjean P.Neurobehavioral Performance of Inuit Children with Increased Prenatal Exposure to Methylmercury. Int J Circumpolar Health 2002; 61: 41-9. Philippe Grandjean and Roberta F. White : Neurobehavioral dysfunctionas as possible sentinel of methylmercury exposure. Human and Ecological Risk Assessment. Paper presented at the 5th NHEERL Symposium on Indicators in Health and Ecological Assessment, June 6-8, 2000.
Weihe P, Hoppe H-W, Grandjean P. Sustained high concentrations of pcbs in faroese pregnant women despite dietary intervention. Organohalogen Comp 2003; 63: 389-92. 23rd International Symposium on Halogenated Environmental Organic Pollutants and POPs, Boston, Massachusetts, USA, August 24-29, 2003.
Murata K, Dakeishi M, Iwata T. A lesson from the Faroese birth cohort study. Jpn J Environ Sci 2004; 17(3): 169-80.
Philippe Grandjean, Non-precautionary aspects of toxicology. Toxicol Appl Pharmacol.
Weihe P. Prenatal methylmercury exposure in the Seychelles. Lancet 2003; 362(9384): 665.
Keiding N, Budtz-Joergensen E, Grandjean P. Prenatal methylmercury exposure in the Seychelles (letter). Lancet 2003; 362(9384): 664-5.
Grandjean P, Budtz-Jørgensen E, Keiding N, Weihe P. Underestimation of risk due to exposure misclassification. Eur J Oncol 2003; Suppl. 2: 165-72.
Grandjean P. Implications of the Precautionary Principle for public health practice and research. Eur J Oncol 2003; Suppl.2: 17-9.
Budtz-Joergensen E, Keiding N, Grandjean P, Weihe P, White RF. Statistical Methods for the Evalution of Health Effects of Prenatal Mercury Exposure. Environmetrics 2003; 14: 105-20.
Grandjean, Philippe MD, PhD; White, Roberta F. PhD; Weihe, Pal MD; Joergensen, Poul J. MSc Neurotoxic Risk Caused by Stable and Variable Exposure to Methylmercury from Seafood. Ambul Pediatr 2003; 3(1): 18-23.
Budtz-Joergensen E, Keiding N, Grandjean P, Weihe P, White RF. Consequences of exposure measurement error for confounder identification in environmental epidemiology. Stat Med 2003; 22(19): 3089-100.
Rasmussen TH, Nielsen F, Andersen HR, Nielsen JB, Weihe P, Grandjean P. Assessment of xenoestrogenic exposure by a biomarker approach: application of the E-screen bioassay to determine estrogenic response of serum extracts. Environ Health 2003; 2: 12.
Barr DB, Weihe P, Needham LL, Davis MD, Roman W, Hurtz D III, Sclafani A, Thomas A, Preau J Jr, Grandjean P. PCBs and organochlorine pesticide concentrations in a Faroe Island 14-year old cohort: Measurement using new methodology and evaluation of correlations and patterns. Organohalogen Comp 2003; 63: 385-8. 23rd International Symposium on Halogenated Environmental Organic Pollutants and POPs, Boston, Massachusetts, USA, August 24-29, 2003.
Grandjean P. Adverse health effects of PCBs: Interpreting the epidemiological evidence. Organohalogen Comp 2003. 23rd International Symposium on Halogenated Environmental Organic Pollutants and POPs, Boston, Massachusetts, USA, August 24-29, 2003.
Grandjean P, Budtz-Joergensen E, Steuerwald U, Heinzow B, Needham LL, Joergensen PJ, and Weihe P. Attenuated growth of breast-fed children exposed to increased concentrations of methylmercury and polychlorinated biphenyls. FASEB J (online)
Grandjean P, Weihe P. Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposure. Am J Clin Nutr 2003; 77: 715-19.
Heilmann C, Grandjean P, Weihe P. Decreased childhood vaccine response in children exposed to PCBs from maternal seafood diet. Organohalogen Comp 2003; 63: 397-400. 23rd International Symposium on Halogenated Environmental Organic Pollutants and POPs, Boston, Massachusetts, USA, August 24-29, 2003
Budtz-Joergensen E, Keiding N, Grandjean P. Effects of exposure imprecision on estimation of the benchmark dose. Risk Anal 2004; 24(6): 1689-96.
Budtz-Joergensen E, Grandjean P, Joergensen PJ, Weihe P, Keiding N. Association between mercury concentrations in blood and hair in methylmercury-exposed subjects at different ages Environ Res 2004; 95: 385-93.
Murata K, Weihe P, Budtz-Joergensen E, Joergensen PJ, Grandjean P. Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury. J Pediatr 2004; 144: 177-83.
Grandjean P, Murata K, Budtz-Joergensen E, Weihe P. Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort. J Pediatr 2004; 144: 169-76.
Faengstroem B, Strid A, Grandjean P, Weihe P, Bergman C. A retrospective study of PBDEs and PCBs in human milk from the Faroe Islands. Environ Health 2005; 4: 12.
Weihe P, Grandjean P, Joergensen PJ. Application of hair-mercury analysis to determine the impact of a seafood advisory. Environ Res 2005; 97: 200-7.
Faengstroem B, Hovander L, Bignert A, Athanassiadis I, Linderholm L, Grandjean P, Weihe P, Bergman C. Concentrations of PBDEs, PCBs, and OH-PCBs in serum from seven-year-old children and their mothers during pregnancy. Environ Sci Technol 2005; 39(24): 9457-63.
Faengstroem B, Athanasiadou M, Athanassiadis I, Bignert A, Grandjean P, Weihe P, Bergman A. Polybrominated diphenyl ethers and traditional organochlorine pollutants in fulmars (Fulmarus glacialis) from the Faroe Islands. Chemosphere 2005; 60(7): 836-43.
Murata K, Dakeishi M. Neurodevelopmental effects from prenatal exposure to methylmercury in the Seychellois and faroes cohorts and the critical concentration: A review. Nippon Eiseigaku Zasshi 2005 60(1): 4.
Grandjean P, Murata K. Developmental arsenic neurotoxicity in retrospect. Epidemiology 2007 18(1): 25-6.
Grandjean P, Budtz-Joergensen E, Joergensen PJ, Weihe P. Umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury. Environ Health Perspect 2005; 113(7): 905-8.
Halling J, Petersen MS, Damkier P, Nielsen F, Grandjean P, Weihe P, Lundgren S, Sandberg Lundblad MS, Brøsen K. Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population. Eur J Clin Pharmacol 2005; 61(7): 491-7.
Petersen MS, Halling J, Damkier P, Nielsen F, Grandjean P, Weihe P, Broesen K. Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls. Eur J Clin Pharmacol 2006; 62(12):1041-8.
Debes F, Budtz-Jørgensen E, Weihe P, White RF, Grandjean P. Impact of prenatal methylmercury toxicity on neurobehavioral function at age 14 years. Neurotoxicol Teratol 2006; 28(3): 363-75.
Barr DB, Weihe P, Davis MD, Needham LL, Grandjean P. Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort. Chemosphere 2006; 62: 1167-82.
Philippe Grandjean. Seven deadly sins of environmental epidemiology and the virtues of precaution. Epidemiology 2008; 19(1): 158-62.
Debes F, Budtz-Jørgensen E, Weihe P, White RF, Grandjean P. Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Teratol 2006; 28(3): 363–375.
Grandjean P, Landrigan PJ. Developmental neurotoxicity of industrial chemicals. Lancet 2006; 368(9553): 2167-78.
Budtz-Joergensen E, Grandjean P, Weihe P. Separation of risks and benefits of seafood intake. Environ Health Perspect 2007; 115(3): 323-7.
Petersen MS, Halling J, Damkier P, Nielsen F, Grandjean P, Weihe P, Brøsen K. Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults. Toxicol Appl Pharmacol 2007; 224(2): 202-6.
Murata K, Grandjean P, Dakeishi M. Neurophysiological evidence of methylmercury neurotoxicity. Am J Ind Med 2007; 50(10): 765-71.
Budtz-Joergensen E, Keiding N, Grandjean P, Weihe P. Confounder selection in environmental epidemiology: Assessment of health effects of prenatal mercury exposure. Ann Epidemiol 2007; 17(1): 27-35.
Heilmann C, Grandjean P, Weihe P, Nielsen F, Budtz-Joergensen E. Reduced antibody responses to vaccinations in children exposed to polychlorinated biphenyls. PloS Med 2006; 3(8): e311.
Grandjean P. Methylmercury toxicity and functional programming. Reprod Toxicol 2007; 23(3): 414-20.
Choi AL, Budtz-Joergensen E, Joergensen PJ, Steuerwald U, Debes F, Weihe P, Grandjean P. Selenium as a potential protective factor against mercury developmental neurotoxicity. Environ Res 2008; 107(1): 45-52.
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